- Titel: Evolution
- Autor: Manfred Radmacher
- Organisation: UNI BREMEN
- Seitenzahl: 44
Inhalt
- Cellular Biophysics SS Manfred Radmacher
- INSTITUT FÜR BIOPHYSIK
- Probability of a protein being synthesized by chance
- Prof Manfred Radmacher
- Earth used to be a more energetic environment
- Lets rst recall our knowledge on DNA
- From Alberts et al Molecular Cell Biology
- Gen expression is regulated
- DNA is organized in chromosomes in humans
- Cellular Biophysics Ch Evolution
- Information content of the human chromosome
- RNA structure of Q
- Qreplikase generates and replicates without a matrix RNA
- From Sackmann BiophysikSkript
- Eigens experiments on molecular evolution
- Eigens model of molecular evolution
- Derivation on board
- Survival of the ttest
- Due to mutation a quasispecies survives
- Maximum length of genome
- To further increase complexity the hypercycle could help
- Analogy to Laser
- Hermann Haken mode selection Versklavung von Moden
- Linienbreite des Übergangs
- Adsorption spontane Emission stimulierte Emission Besetzungsinversion N N
- f Moden Eigenschwingungen L ncfn
- Spektrallinie Moden des Resonators f
- Versklavung von Moden
- Rybozymes Hammerhead rybozyme shows enzymatic activity
Vorschau
Cellular Biophysics SS 20007 Manfred Radmacher
Ch. 08 Evolution
INSTITUT FÜR BIOPHYSIK
Universität Bremen
Probability of a protein being synthesized by chance
typical protein has 100 amino acids there are 20 different amino acids there are 20100 different amino acid sequences of this length this is: 1.3 * 10130 the probability that this protein evolved by chance is: 0.7 * 10-130 so, this (and all other) proteins can’t have evolved by trying out all possibilities
Cellular Biophysics
Ch. 08 Evolution
INSTITUT FÜR BIOPHYSIK
Universität Bremen
Prof. Manfred Radmacher
Gedankenexperiment
let’s take a protein solution at 1 mMol this is 6 * 1020 molecules per liter times the volume of the ocean: 0.7 * 4 * π (6000 km)2 * 1500 m = 5 * 1020 ltr this is 3 * 1041 molecules on earth synthesize them newly every second (by mutation or whatever) and multiply it by the age of the universe: 10 * 109 years = 3 * 1017 seconds gives a total of 9 * 1058 molecules synthesized